GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs5758659 | 1 | rs134902 | chr22:42683997 | CYP2D6 | chr22:42522502-42526883:- | -0.35 | -7.53 | 3.57E-13 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs134902 | chr22:42683997 | NAGA | chr22:42454339-42466846:- | 0.24 | 4.38 | 1.51E-5 | Cognitive function |
| BLCA | cis | rs7112513 | 1 | rs1351452 | chr11:116943354 | PCSK7 | chr11:117075789-117102811:- | 0.38 | 4.93 | 1.25E-6 | Protein quantitative trait loci |
| BLCA | cis | rs10935120 | 1 | rs1357762 | chr3:134264859 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.54 | 3.54E-13 | Height |
| BLCA | cis | rs2028299 | 1 | rs1371135 | chr15:90391270 | AP3S2 | chr15:90373832-90456222:- | -0.7 | -10.55 | 5.08E-23 | Type 2 diabetes |
| BLCA | cis | rs137115 | 1 | rs137115 | chr22:43011403 | SERHL | chr22:42896585-42968535:+ | 0.38 | 5.01 | 8.22E-7 | Parental extreme longevity (95 years and older) |
| BLCA | cis | rs798766 | 1 | rs1374469 | chr4:1724799 | FAM53A | chr4:1641609-1685854:- | -0.33 | -4.9 | 1.44E-6 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs76419734 | 1 | rs1374531 | chr4:106523932 | INTS12 | chr4:106603787-106629881:- | -0.46 | -3.91 | 0.000108 | Post bronchodilator FEV1 |
| BLCA | cis | rs9303401 | 1 | rs1390006 | chr17:56890663 | RAD51C | chr17:56769963-56811690:+ | -0.28 | -5.03 | 7.47E-7 | Cognitive test performance |
| BLCA | cis | rs2243480 | 1 | rs1392104 | chr7:65759107 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.72 | 3.27E-6 | Diabetic kidney disease |
| BLCA | cis | rs1392635 | 1 | rs1392635 | chr15:69398026 | CALML4 | chr15:68483044-68498448:- | 0.24 | 3.88 | 0.000122 | Lipoprotein-associated phospholipase A2 activity change in response to statin therapy |
| BLCA | cis | rs1401999 | 1 | rs1401999 | chr3:183678342 | VWA5B2 | chr3:183948317-183960116:+ | -0.24 | -3.91 | 0.00011 | Anterior chamber depth |
| BLCA | cis | rs1401999 | 1 | rs1402002 | chr3:183642794 | VWA5B2 | chr3:183948317-183960116:+ | -0.23 | -3.86 | 0.000131 | Anterior chamber depth |
| BLCA | cis | rs1401999 | 1 | rs1402003 | chr3:183642879 | ABCC5 | chr3:183637726-183735727:- | -0.2 | -3.92 | 0.000104 | Anterior chamber depth |
| BLCA | cis | rs1401999 | 1 | rs1402003 | chr3:183642879 | VWA5B2 | chr3:183948317-183960116:+ | -0.25 | -4.03 | 6.6E-5 | Anterior chamber depth |